Dialogue with Dr. Rubini, A World Leader in Animal Contrast Imaging

Shaping the Future from the Present

2024-04-23

Ultrasound, known for its safety and radiation-free nature, has long been an essential tool for veterinarians in diagnosing diseases. With the rise of scientific feeding practices, pets are living longer with an increase in elderly animals who are more prone to multiple chronic diseases.

Currently, contrast-enhanced ultrasound (CEUS) imaging technique is at the forefront of the “third ultrasound revolution”. Offering clearer images of blood flow and tissues, it enables veterinarians to better diagnose conditions affecting the liver, spleen, pancreas, lymph nodes, heart of elderly animals more accurately, facilitating timely treatment.


In the CEUS revolution, Dr. Giuseppe Rubini, a global pioneer in animal contrast ultrasound, is leading the industry with his profound expertise and extensive practical experience.

Dr. Giuseppe Rubini

Pace-setter in Animal Contrast Ultrasound Imaging
Founder of Ultravet Diagnostic, specialistic ultrasound diagnostic imaging centre (Italy)
Lecturer at the Second Level Master in Specialized Ultrasonology in Small Animal Veterinary Medicine (University of Bologna, 2012 edition)
Second Level Master in Dagnostic Imaging of Small Animal (University of Teramo, 2023)

Dr. Rubini's clinical and research work cover also elastography, stem cell therapy, and exosomal therapy, and exosomal therapy, with his findings published in top journals such as Scientific Reports and 《Animals (Basel)》. His books and numerous academic papers have contributed significantly to the precision of animal disease diagnosis and the early detection and treatment of illnesses.

A distinguished educator, Dr. Rubini has been offering ultrasound diagnostic programs in Italy since 2000, shaping the careers of many exceptional professionals. He has shared knowledge and insights with students and colleagues worldwide, earning him acclaim and respect, both in Italy and internationally.

Experts Gathered in Shenzhen to Explore the Latest Global Trends in Contrast Imaging

Invited by Mindray Animal Medical, Dr. Rubini recently traveled to China to showcase latest advancements in animal contrast-enhanced ultrasound, injecting innovative vitality into the industry.

Dr. Rubini's visit started in Shenzhen, where he presented cutting-edge insights into the application of contrast ultrasound and engaged in discussions with global animal medical industry elites about the future of ultrasound imaging in veterinary medicine.

As one important element in combination of different imaging modes to deliver multiparametric ultrasonography, contrast-enhanced ultrasound technology, as being stated in human medicine, it performs at level comparable to, and in some cases even surpassing, that of CT and MRI.

Dr. Giuseppe Rubini

Pace-setter in Animal Contrast Ultrasound Imaging
Founder of Ultravet Diagnostic, specialistic ultrasound diagnostic imaging centre (Italy)
Lecturer at the Second Level Master in Specialized Ultrasonology in Small Animal Veterinary Medicine (University of Bologna, 2012 edition)
Second Level Master in Dagnostic Imaging of Small Animal (University of Teramo, 2023)

So, when should contrast-enhanced ultrasound be used for diagnosing and treating hepatic disease? Authoritative guidelines advise that after identifying a focal lesion on a standard ultrasound, contrast-enhanced ultrasound should be the first follow-up test.
I am particularly impressed by UWN+ contrast imaging, which utilizes non-linear fundamental and second harmonic signals. It not only generates significantly enhanced images, but also greatly prolongs agent duration, offering a robust foundation for accurate diagnosis.

Sources of authoritative guidelines: ' Dietrich CF, Nolsge CP, Barr RG, Berzigotti A, Burns PN, Cantisani v, Chammas MC, Chaubal N, Choi BlClevert DA, Cui X, Dong Y, D'Onofrio M, Fowlkes JB, Gilja OH, Huang P, lgnee A, Jenssen C, Kono Y, KudoM, Lassau N, Lee WJ, Lee JY, Liang P, Lim A, Lyshchik A, MeloniM, Correas JM, Minami Y, Moriyasu F,Nicolau C, Piscaglia F, Saftoiu A, Sidhu PS, Sporea l, Torzilli G, Xie X, Zheng R. Guidelines and GoodClinical Practice Recommendations for Contrast-Enhanced Ultrasound (CEUS) in the Liver-Update 2020WFUMB in Cooperation with EFSUMB, AFSUMB, AIUM, and FLAUS. Ultrasound Med Biol. 2020Oct;46(10):2579-2604.doi: 10.1016/iultrasmedbio.2020.04.030.Epub 2020Ju124.PMID:32713788.

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Dr. Rubini's presentation highlighted the crucial role of ultrasound in contemporary veterinary imaging and promising directions for its future advancement. Guided by his expertise, the global experts in attendance unanimously agreed: “Contrast imaging not only defines the present but also represents the future trend!”

Visit to China Agricultural University: Shaping the Future of China-Italy Ultrasound Collaboration

Dr. Rubini's academic exchange journey continued from the warm southern region to Beijing, where he visited China Agricultural University Veterinary Teaching Hospital (CAUVTH) — China's premier institution for veterinary imaging and the largest single-site animal hospital in the country.

During his visit, Dr. Rubini was notably impressed by the hospital's professionalism and cutting-edge facilities. By learning about the hospital's operation and facilities, he commended the modern equipment and efficient workflows, expressing admiration for China's rapid development in veterinary medicine.

The visit featured an engaging discussion between Chinese and Italian experts on “Advancements in the Application of Clinical Veterinary Contrast-Enhanced Ultrasonography”. Following Dr. Rubini's exclusive sharing, CAUVTH specialists provided valuable feedback and participated in dynamic discussions, particularly on early detection, precise diagnosis, and treatment monitoring of internal diseases and tumors.

Fu Mengzhu

Director of Imaging Department
China Agricultural University Teaching Animal Hospital (CAUVTH)

After engaging with Dr. Rubini, I've come to see the tremendous development potential in the field of contrast-enhanced ultrasound in China, particularly in terms of case volume and diagnostic diversity. We are committed to ongoing investment to actively advance the progress of veterinary imaging.
Dai Rongquan

Head of Imaging Specialty
China Agricultural University Teaching Animal Hospital (CAUVTH)

Dr. Rubini's insights have greatly enhanced my understanding of how contrast-enhanced ultrasound can transform clinical practice. With advanced hospitals in China beginning to adopt this technology and the increasing availability of related equipment, contrast-enhanced ultrasound is set to play a pivotal role in more veterinary institutions. I am confident that its future is promising.

The exchange at CAUVTH has significantly strengthened the collaboration and mutual understanding between domestic experts and Dr. Rubini. This event was not only a valuable knowledge-sharing opportunity but also an international platform for collective growth. I look forward to more such global exchange opportunities, where China and the international community can collaborate to advance and enrich the field of veterinary medicine.”

Endless Innovation: Unveiling a New Chapter in Animal Ultrasound Technology

Accurate clinical diagnosis hinges on high-performance imaging technologies and equipment. With the continuous advancement of medical technology and the increasing demand for precise clinical diagnostics, Mindray Animal Medical introduces Ultra-Wideband Non-linear Plus (UWN+) contrast imaging technology.

Utilizing Mindray Animal Medical ZONE Sonography® Technology+ (ZST+), UWN+ contrast imaging utilizes non-linear fundamental wave imaging to significantly enhance imaging signal strength, making deep tissue imaging in animals more efficient and accurate.

Moreover, UWN+ ingeniously combines second harmonic imaging to further improve image resolution, allowing for more precise visualization of tissue boundaries and structures, thereby providing veterinarians with clearer diagnostic images.

By optimizing contrast signal strength while minimizing mechanical index, it ensures longer imaging times and reduced contrast agent usage, providing safer and more effective care for patients.


Dr. Rubini's academic exchange visit to China may have ended, but Mindray Animal Medical's commitment to global collaboration continues. Beyond providing state-of-the-art devices and technology, Mindray Animal Medical actively promotes international dialogue, driving high-quality advancements in the industry and shaping the future of animal health.

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